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Zapun A, Vernet T, Pinho MG. The different shapes of cocci. FEMS Microbiol Rev. Sauvage E, Kerff F, Terrak M, Ayala JA, Charlier P.

The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis. Yocum RR, Waxman DJ, Rasmussen JR, Strominger JL. Mechanism of penicillin action: penicillin and substrate bind covalently to the same active site serine in two bacterial d -alanine carboxypeptidases.

Proc Natl Acad Sci USA. Zapun A, Contreras-Martel C, Vernet T. Penicillin-binding proteins and beta-lactam resistance.

Scheffers DJ, Pinho MG. Bacterial cell wall synthesis: new insights from localization studies. Wada A, Watanabe H. Penicillin-binding protein 1 of Staphylococcus aureus is essential for growth.

J Bacteriol. Leski TA, Tomasz A. Role of penicillin-binding protein 2 PBP2 in the antibiotic susceptibility and cell wall cross-linking of Staphylococcus aureus : evidence for the cooperative functioning of PBP2, PBP4, and PBP2A.

Wyke AW, Ward JB, Hayes MV, Curtis NAC. A role in vivo for penicillin-binding protein-4 of Staphylococcus aureus.

Pinho MG, de Lencastre H, Tomasz A. Cloning, characterization, and inactivation of the gene pbpC, encoding penicillin-binding protein 3 of Staphylococcus aureus.

Derbise A, Song YP, Parikh S, Fischetti VA, Pancholi V. Role of the C-terminal lysine residues of streptococcal surface enolase in Glu- and Lys-plasminogen-binding activities of group A streptococci.

Wistedt AC, Ringdahl U, Müller-Esterl WSU. Identification of a plasminogen-binding motif in PAM, a bacterial surface protein. Sanderson-Smith ML, Dowton M, Ranson M, Walker MJ.

The plasminogen-binding group A streptococcal M protein-related protein Prp binds plasminogen via arginine and histidine residues.

Schenone MM, Warder SE, Martin JA, Prorok M, Castellino FJ. An internal histidine residue from the bacterial surface protein, PAM, mediates its binding to the kringle-2 domain of human plasminogen.

J Pept Res. Griffin JD, Ellman L. Epsilon-aminocaproic acid EACA. Semin Thromb Hemost. Silva MMCG, Thelwell C, Williams SC, Longstaff C.

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Muthukrishnan G, Quinn GA, Lamers RP, Diaz C, Cole AL, Chen S, Cole AM. Exoproteome of Staphylococcus aureus reveals putative determinants of nasal carriage.

J Proteome Res. Surfaceome and exoproteome of a clinical sequence type methicillin resistant Staphylococcus aureus strain.

Biochem Biophy Rep. Google Scholar. Gurung M, Moon DC, Choi CW, Lee JH, Bae YC, Kim J, Lee YC, Seol SY, Cho DT, Kim SI, Lee JC. Staphylococcus aureus produces membrane-derived vesicles that induce host cell death.

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A novel secreted metalloprotease CD from Clostridium difficile cleaves specific proline sequences in LPXTG cell surface proteins.

Mol Cell Proteomics. Pacheco LG, Slade SE, Seyffert N, Santos AR, Castro TL, Silva WM, Santos AV, Santos SG, Farias LM, Carvalho MA, Pimenta AM, Meyer R, Silva A, Scrivens JH, Oliveira SC, Miyoshi A, Dowson CG, Azevedo V.

There are plenty of other massage parlours in and around the city where you can get a tantric treat. Most provide a happy ending service but if you are looking for something more then you are better off trying one of the brothels or FKK clubs.

Cologne does have one dedicated lap dancing venue see below and some burlesque style entertainment clubs. If you want to arrange a striptease act for a private event then you could use the Devotion Agency.

Escorts may also be willing to provide private strip performances but do check when booking as their fees may be more for an audience.

One of the oldest American-style table dance venues in Germany, the Stardust is situated in the west of the city between the Rudolfplatz and Friesenplatz underground stations.

There are private cabins for one-to-one dances and you can even pay for the company of one of the dancers to join you for an evening, much like in an Asian hostess bar.

The Stardust offers American-style strip and table dancing in a very familiar setting. The Kokett Bar has been entertaining guests to Cologne since and has a traditional Art Deco charm.

Evening shows are burlesque in style and there is even free table dancing to enjoy. Be aware that if you are getting a taxi to the Kokett Bar, there are some drivers who will inform you that the club has closed or moved location.

This is an ongoing scam with cabbies delivering tourists to overpriced clubs instead. The Kokett Bar is an iconic strip club in Cologne with a classy feel.

The Kokett Bar is open Monday to Saturday from 9. During the Trade Fair, the club also opens on Sundays. Prior to the s, Cologne used to have several red-light areas but the city authorities made an attempt to condense sex work by authorising the building of two high-rise brothels.

Consisting of a series of shelters, the facilities were designed for hookers to service clients in their cars. There are wash facilities on site as well as panic buttons and welfare services.

The booths are designed so the driver must park close to the left hand wall so he cannot leave the vehicle. An alarm and safe area is available to the right of the box so that hookers can exit the vehicle and get to a place of safety if they feel the need.

Both the drive-ins and super-brothels have largely been successful and the city has fewer street prostitutes although there are some areas where you can still pick up in the traditional way.

Transport hubs are popular places for street hookers to solicit. Image via Pixabay. Though less common, you can find working women around the train station and cathedral in the city of Cologne.

There is no red-light district as such in Cologne and you can find brothels, clubs and sex shops across the city.

Op het pad kom je. On the path you will. Antjie Krog en Kristien. Antjie Krog and Kristien. Current searches: esperanto , filter , spreeuw , cumul , handelsnaam , troch , doorzichtig , volunteer , toevoeging , snowy , volkeren , barba , tonnen , portico , ongelijk.

Please click on the reason for your vote: This is not a good example for the translation above. The wrong words are highlighted.

It does not match my search. It should not be summed up with the orange entries The translation is wrong or of bad quality. According to historians, Alexander invaded India following his desire to reach the "ends of the world and the Great Outer Sea.

Alexander's desire to reach "the ends of the Earth" was instilled by his tutor Aristotle :. This view of the world taught by Aristotle and followed by Alexander is apparent in Aristotle's Meteorologica , a treatise on earth sciences where he discusses the "length" and "width" of "the inhabited earth.

Aristotle's cosmological view was that the Earth is round but he prescribed to the notion of an "inhabited Earth," surrounded by the Ocean, and an "uninhabited Earth" though exactly how much of this was understood by his student Alexander the Great is not known.

Alexander the Great features prominently in early Arabic literature. There are many surviving versions of the Alexander romance in Arabic that were written after the conquest of Islam.

It is also thought that pre-Islamic Arabic versions of the Alexander romance may have existed. The earliest surviving Arabic narrative of the Alexander romance was composed by Umara ibn Zayd — AD.

In the tale, Alexander travels a great deal, builds the Wall against Gog and Magog, searches for the Water of Life Fountain of Youth , and encounters angels who give him a "wonder-stone" that both weighs more than any other stone but is also as light as dust.

This wonder-stone is meant to admonish Alexander for his ambitions and indicate that his lust for conquest and eternal life will not end until his death.

The story of the wonder-stone is not found in the Syriac Christian legend, but is found in Jewish Talmudic traditions about Alexander as well as in Persian traditions.

A South Arabian Alexander legend was written by the Yemenite traditionist Wahb ibn Munabbih? In the Yemenite variation, Dhul-Qarnayn is identified with an ancient king of Yemen named Tubba' , rather than Alexander the Great, but the Arabic story still describes the story of Alexander's Wall against Gog and Magog and his quest for the Water of Life.

The story also mentions that Dhul-Qarnayn Tubba' visited a castle with glass walls and visited the Brahmins of India. The South Arabian legend was composed within the context of the division between the South Arabs and North Arabs that began with the Battle of Marj Rahit in AD and consolidated over two centuries.

The Alexander romance also had an important influence on Arabic wisdom literature. In Secretum Secretorum "Secret of Secrets", in Arabic Kitab sirr al-asrar , an encyclopedic Arabic treatise on a wide range of topics such as statecraft , ethics , physiognomy , alchemy , astrology , magic and medicine , Alexander appears as a speaker and subject of wise sayings and as a correspondent with figures such as Aristotle.

The origins of the treatise are uncertain. No Greek original exists, though there are claims in the Arabic treatise that it was translated from the Greek into Syriac and from Syriac into Arabic by a well-known 9th century translator, Yahya ibn al-Bitriq?

It appears, however, that the treatise was actually composed originally in Arabic. In another example of Arabic wisdom literature relating to Alexander, Ibn al-Nadim?

Notably, the Abbasid Caliph Al-Mu'tasim — AD had ordered the translation of the Thesaurus Alexandri , a work on elixirs and amulets , from Greek and Latin into Arabic.

The Greek work Thesaurus Alexandri was attributed to Hermes the great messenger of the gods in Greek mythology and similarly contained supposed letters from Aristotle addressed to Alexander.

A more direct Arabic translation of the Alexander romance, called Sirat Al-Iskandar , was discovered in Constantinople , at the Hagia Sophia , and is dated to the 13th century.

This version includes the letter from Alexander to his mother about his travels in India and at the end of the World. It also includes features which occur exclusively in the Syriac version.

The Arabic legend also retains certain pagan elements of the story, which are sometimes modified to suit the Islamic message:.

It is quite remarkable that some characteristics belonging to a pre-Islamic 'pagan' entourage, have survived in the text For example, Alexander orders an offering of sacrificial animals at the temple of Hercules.

In the Arabic letter the name of the deity has been replaced by Allah Another passage in the account of the palace of Shoshan or Sus, gives a description of the large silver jars, which were alleged to have capacity of three hundred and sixty measures of wine.

Alexander puts this assertion to the test, having one of the jars filled with wine and poured out for his soldiers during a banquet.

This exact specification has been maintained, heedless of the Islamic ban on the use of wine These retouched borrowings are highly significant in this text, because the Arabic Alexander figure is portrayed as a propagator of Islamic monotheism.

Another piece of Arabic Alexander literature is the Laments or Sayings of the Philosophers. These are a collection of remarks supposedly made by some philosophers gathered at the tomb of Alexander after his death.

This legend was originally written in the 6th century in Syriac and was later translated into Arabic and expanded upon. The Laments of the Philosophers eventually gained enormous popularity in Europe: [17].

Hunayan's version was translated into Spanish The Arabic Alexander romance also had an influence on a wider range of Arabic literature.

It has been noted that some features of the Arabic Alexander legends found their way into The Seven Voyages of Sinbad the Sailor , a medieval story-cycle of Arabic origin.

Sinbad, the hero of the epic, is a fictional sailor from Basrah , living during the Abbasid Caliphate. During his voyages throughout the seas east of Africa and south of Asia, he has fantastic adventures going to magical places, meeting monsters, and encountering supernatural phenomena.

As a separate example of this influence on Arabic literature, the legend of Alexander's search for the Water of Life is found in One Thousand and One Nights , a collection of Middle Eastern and South Asian stories and folktales compiled in Arabic during the Islamic Golden Age.

An Arabic derivative of the Alexander romance was produced, called Qisas Dhul-Qarnayn Tales of Dhul-Qarnayn. By the turn of the first millennium C.

Interwoven later into this narrative in the Tales of the Prophets literature were episodes of an apparent Arab-Islamic elaboration: the construction of a great barrier to keep the people of Gog and Magog from harassing the people of the civilized world until Judgement Day, the voyage to the end of the Earth to witness the sun set in a pool of boiling mud, and Dhu al-Qarnayn's expedition into the Land of Darkness in search of the Fountain of Life accompanied by his companion Khidir "the Green-One".

By AD, the Reconquista was essentially completed and Europeans had retaken the Iberian peninsula from the Muslims, but the Emirate of Granada , a small Muslim vassal of the Christian Kingdom of Castile , remained in Spain until AD.

During the Reconquista, Muslims were forced to either convert to Catholicism or leave the peninsula. The descendants of Muslims who converted to Christianity were called the Moriscos meaning " Moor -like" and were suspecting of secretly practicing Islam.

The Moriscos used a language called Aljamiado , which was a dialect of the Spanish language Mozarabic but was written using the Arabic alphabet.

Aljamiado played a very important role in preserving Islam and the Arabic language in the life of the Moriscos; prayers and the sayings of Muhammad were translated into Aljamiado transcriptions of the Spanish language, while keeping all Quranic verses in the original Arabic.

During this period, a version of the Alexander legend was written in the Aljamaido language, building on the Arabic Qisas Dhul-Qarnayn legends as well as Romance language versions of the Alexander romance.

With the Muslim conquest of Persia in AD, the Alexander romance found its way into Persian literature —an ironic outcome considering pre-Islamic Persia's hostility towards the national enemy who conquered the Achaemenid Empire and was directly responsible for centuries of Persian domination by Hellenistic foreign rulers.

However, he is not depicted as a warrior and conqueror, but as a seeker of truth who eventually finds the Ab-i Hayat Water of Life.

For example, Pseudo-Callisthenes is the source of many incidents in the Shahnama written by Ferdowsi — AD in New Persian. Persian sources on the Alexander legend devised a mythical genealogy for him whereby his mother was a concubine of Darius II , making him the half-brother of the last Achaemenid shah , Darius.

By the 12th century such important writers as Nizami Ganjavi from Ganja , Azerbaijan were making him the subject of their epic poems.

The Muslim traditions also elaborated the legend that Alexander the Great had been the companion of Aristotle and the direct student of Plato.

There is also evidence that the Syriac translation of the Alexander romance , dating to the 6th century, was not directly based on the Greek recensions but was based on a lost Pahlavi pre-Islamic Persian manuscript.

Certain Muslim people of Central Asia , specifically Bulgar , Tatar and Bashkir peoples of the Volga - Ural region within what is today Tatarstan in the Russian Federation , carried on a rich tradition of the Alexander legend well into the 19th century.

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